منابع مشابه
Not too much and not too little.
The structure and function of any protein is determined by its amino acid sequence. Thus, the substitution of one amino acid for another can alter the activity of a protein or its function. Mutations—or rather, polymorphism, once they become fixed in the population—can be deleterious, such that the altered protein is no longer able to fulfil its role with potentially devastating effects on the ...
متن کاملNot too late, not too fast!!
This editorial refers to ‘A simplified biventricular defibrillator with fixed long detection intervals reduces implantable cardioverter defibrillator (ICD) interventions and heart failure hospitalizations in patients with non-ischaemic cardiomyopathy implanted for primary prevention: the RELEVANT [Role of long dEtection window programming in patients with LEft VentriculAr dysfunction, Non-ische...
متن کاملTrace Minerals and Livestock: Not Too Much Not Too Little
The new approaches of the animal production systems make managing the mineral nutrition a challenge. Versus the excessive, trace mineral supply in intensively managed livestock, well above the physiological requirements, is the no trace mineral supplementation of organic systems, which become highly dependent on trace minerals in the soil. Nowadays, in addition to the animal health perspective,...
متن کاملNiger: too little, too late.
Niger—with the world’s fastest growing population, its highest total fertility rate (TFR), a small and diminishing amount of arable land, low annual rainfall, a high level of malnutrition, extremely low levels of education, gross gender inequities and an uncertain future in the face of climate change—is the most extreme example of a catastrophe that is likely to overtake the Sahel. The policies...
متن کاملLetter from . . . Denmark. Too much, not too little?
I Holmes, L. B., et al., Atlas of Mental Retardation. New York and London, 1972. 2 Caffey, J., Pediatrics, 1974, 54, 396. ' Mac Keith, R., Developmental Medicine and Child Neurology, 1974, 16, 216. 4 Smith, S. M., and Hanson, R., British Medical Journal, 1974, 3, 666. B Oliver, J. E., et al., Severely Ill-treated Young Children in North-east Wiltshire. Oxford University of Clinical Epidemiology...
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ژورنال
عنوان ژورنال: Circulation
سال: 2018
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.118.036600